Iron and nickel complexes with heterocyclic ligands: stability, synthesis, spectral characterization, antimicrobial activity, acute and subacute toxicity.
Identifieur interne : 000130 ( Main/Exploration ); précédent : 000129; suivant : 000131Iron and nickel complexes with heterocyclic ligands: stability, synthesis, spectral characterization, antimicrobial activity, acute and subacute toxicity.
Auteurs : Afaf Bouchoucha [Algérie] ; Achour Terbouche ; Mohamed Zaouani ; Fazia Derridj ; Safia DjebbarSource :
- Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [ 1878-3252 ] ; 2013.
English descriptors
- KwdEn :
- Animals, Anti-Infective Agents (chemistry), Anti-Infective Agents (pharmacology), Anti-Infective Agents (toxicity), Bacteria (drug effects), Dose-Response Relationship, Drug, Female, Fungi (drug effects), Heterocyclic Compounds (chemistry), Iron (chemistry), Lethal Dose 50, Ligands, Male, Mice, Mice, Inbred Strains, Microbial Sensitivity Tests, Molecular Structure, Nickel (chemistry), Organometallic Compounds (chemistry), Organometallic Compounds (pharmacology), Organometallic Compounds (toxicity), Rats, Rats, Wistar, Structure-Activity Relationship.
- MESH :
- chemical , chemistry : Anti-Infective Agents, Heterocyclic Compounds, Iron, Nickel, Organometallic Compounds.
- chemical , pharmacology : Anti-Infective Agents, Organometallic Compounds.
- chemical , toxicity : Anti-Infective Agents, Organometallic Compounds.
- drug effects : Bacteria, Fungi.
- Animals, Dose-Response Relationship, Drug, Female, Lethal Dose 50, Ligands, Male, Mice, Mice, Inbred Strains, Microbial Sensitivity Tests, Molecular Structure, Rats, Rats, Wistar, Structure-Activity Relationship.
Abstract
The synthesis and characterization by elemental analysis, emission atomic spectroscopy, TG measurements, magnetic measurements, FTIR, (1)H NMR, UV-visible spectra and conductivity of a series of iron (II) and nickel (II) complexes with two heterocyclic ligands (L(1)(SMX): sulfamethoxazole and L(2)(MIZ): metronidazole) used in pharmaceutical field and with a new ligand derived benzoxazole (L(3)(MPBO): 2-(5-methylpyridine-2-yl)benzoxazole), were reported. The formulae obtained for the complexes are: [M(L(1))2 Cl2]·nH2O, [M(L(2))2Cl2(H2O)2]·H2O and [M(L(3))2(OH)2]·nH2O. Stability constants of these complexes have been determined by potentiometric methods in water-ethanol (90:10, v/v) mixture at a 0.2 mol L(-1) ionic strength (NaCl) and at 25.0±0.1 °C. Sirko program was used to determine the protonation constants as well as the binding constants of three species [ML2H2](2+), [ML2] and [ML](2+). The antimicrobial activity of the ligands and complexes was evaluated in vitro against different human bacteria and fungi using agar diffusion method. Iron sulfamethoxazole complex showed a remarkable inhibition of bacteria growth especially on Staphylococcus aureus and P. aeruginosa. The iron metronidazole complex is active against yeasts especially on Candida tropicalis strain. Nickel complexes presented different antibacterial and antifungal behavior's against bacteria and fungal. The acute toxicity study revealed that the iron complexes are not toxic at 2000 mg/kg dose orally administrated. LD50 for nickel complexes was determined using graphical method. No significant differences in the body weights between the control and the treated groups of both rat sexes in subacute toxicity study using for iron complexes. Hematological and clinical blood chemistry analysis revealed no toxicity effects of the iron complexes. Pathologically, neither gross abnormalities nor histopathological changes were observed for these complexes.
DOI: 10.1016/j.jtemb.2012.12.001
PubMed: 23380153
Affiliations:
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Laboratory, Faculty of Chemistry, Houari Boumediene Technologies Sciences University, BP 32, El Alia, Algiers, Algeria.</nlm:affiliation><country xml:lang="fr">Algérie</country><wicri:regionArea>Hydrometallurgy and Molecular Inorganic Chemistry Laboratory, Faculty of Chemistry, Houari Boumediene Technologies Sciences University, BP 32, El Alia, Algiers</wicri:regionArea><placeName><settlement type="city">Alger</settlement><region nuts="2">Wilaya d'Alger</region></placeName></affiliation></author><author><name sortKey="Terbouche, Achour" sort="Terbouche, Achour" uniqKey="Terbouche A" first="Achour" last="Terbouche">Achour Terbouche</name></author><author><name sortKey="Zaouani, Mohamed" sort="Zaouani, Mohamed" uniqKey="Zaouani M" first="Mohamed" last="Zaouani">Mohamed Zaouani</name></author><author><name sortKey="Derridj, Fazia" sort="Derridj, Fazia" uniqKey="Derridj F" first="Fazia" last="Derridj">Fazia Derridj</name></author><author><name sortKey="Djebbar, Safia" sort="Djebbar, Safia" uniqKey="Djebbar S" first="Safia" last="Djebbar">Safia Djebbar</name></author></analytic><series><title level="j">Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)</title><idno type="eISSN">1878-3252</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Anti-Infective Agents (chemistry)</term><term>Anti-Infective Agents (pharmacology)</term><term>Anti-Infective Agents (toxicity)</term><term>Bacteria (drug effects)</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Fungi (drug effects)</term><term>Heterocyclic Compounds (chemistry)</term><term>Iron (chemistry)</term><term>Lethal Dose 50</term><term>Ligands</term><term>Male</term><term>Mice</term><term>Mice, Inbred Strains</term><term>Microbial Sensitivity Tests</term><term>Molecular Structure</term><term>Nickel (chemistry)</term><term>Organometallic Compounds (chemistry)</term><term>Organometallic Compounds (pharmacology)</term><term>Organometallic Compounds (toxicity)</term><term>Rats</term><term>Rats, Wistar</term><term>Structure-Activity Relationship</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Infective Agents</term><term>Heterocyclic Compounds</term><term>Iron</term><term>Nickel</term><term>Organometallic Compounds</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Infective Agents</term><term>Organometallic Compounds</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Anti-Infective Agents</term><term>Organometallic Compounds</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Bacteria</term><term>Fungi</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Lethal Dose 50</term><term>Ligands</term><term>Male</term><term>Mice</term><term>Mice, Inbred Strains</term><term>Microbial Sensitivity Tests</term><term>Molecular Structure</term><term>Rats</term><term>Rats, Wistar</term><term>Structure-Activity Relationship</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The synthesis and characterization by elemental analysis, emission atomic spectroscopy, TG measurements, magnetic measurements, FTIR, (1)H NMR, UV-visible spectra and conductivity of a series of iron (II) and nickel (II) complexes with two heterocyclic ligands (L(1)(SMX): sulfamethoxazole and L(2)(MIZ): metronidazole) used in pharmaceutical field and with a new ligand derived benzoxazole (L(3)(MPBO): 2-(5-methylpyridine-2-yl)benzoxazole), were reported. The formulae obtained for the complexes are: [M(L(1))2 Cl2]·nH2O, [M(L(2))2Cl2(H2O)2]·H2O and [M(L(3))2(OH)2]·nH2O. Stability constants of these complexes have been determined by potentiometric methods in water-ethanol (90:10, v/v) mixture at a 0.2 mol L(-1) ionic strength (NaCl) and at 25.0±0.1 °C. Sirko program was used to determine the protonation constants as well as the binding constants of three species [ML2H2](2+), [ML2] and [ML](2+). The antimicrobial activity of the ligands and complexes was evaluated in vitro against different human bacteria and fungi using agar diffusion method. Iron sulfamethoxazole complex showed a remarkable inhibition of bacteria growth especially on Staphylococcus aureus and P. aeruginosa. The iron metronidazole complex is active against yeasts especially on Candida tropicalis strain. Nickel complexes presented different antibacterial and antifungal behavior's against bacteria and fungal. The acute toxicity study revealed that the iron complexes are not toxic at 2000 mg/kg dose orally administrated. LD50 for nickel complexes was determined using graphical method. No significant differences in the body weights between the control and the treated groups of both rat sexes in subacute toxicity study using for iron complexes. Hematological and clinical blood chemistry analysis revealed no toxicity effects of the iron complexes. Pathologically, neither gross abnormalities nor histopathological changes were observed for these complexes.</div></front></TEI><affiliations><list><country><li>Algérie</li></country><region><li>Wilaya d'Alger</li></region><settlement><li>Alger</li></settlement></list><tree><noCountry><name sortKey="Derridj, Fazia" sort="Derridj, Fazia" uniqKey="Derridj F" first="Fazia" last="Derridj">Fazia Derridj</name><name sortKey="Djebbar, Safia" sort="Djebbar, Safia" uniqKey="Djebbar S" first="Safia" last="Djebbar">Safia Djebbar</name><name sortKey="Terbouche, Achour" sort="Terbouche, Achour" uniqKey="Terbouche A" first="Achour" last="Terbouche">Achour Terbouche</name><name sortKey="Zaouani, Mohamed" sort="Zaouani, Mohamed" uniqKey="Zaouani M" first="Mohamed" last="Zaouani">Mohamed Zaouani</name></noCountry><country name="Algérie"><region name="Wilaya d'Alger"><name sortKey="Bouchoucha, Afaf" sort="Bouchoucha, Afaf" uniqKey="Bouchoucha A" first="Afaf" last="Bouchoucha">Afaf Bouchoucha</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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